Amylyx Pharmaceuticals Announces Partnership Agreement with Sunnybrook Research Institute to Identify Novel Drug Candidates for Neurodegenerative Diseases
- Project to support identification of Bax and Bak inhibitor therapeutic candidates with the potential to treat ALS and other neurodegenerative diseases
“We have been closely following research into Bax and Bak inhibition considering the criticality of these proteins in pathways of cell death and axonal degeneration and the work that has been done on these pathways in ALS. We are excited about the work conducted at SRI which we believe could be important for ALS and other neurodegenerative diseases,” said
ALS is a relentlessly progressive and fatal neurodegenerative disorder caused by motor neuron death in the brain and spinal cord. Motor neuron loss in ALS leads to deteriorating muscle function, the inability to move and speak, respiratory paralysis, and eventually death. The pathophysiologic mechanisms leading to motor neuron death in ALS are multifactorial and include programmed cell death pathways involving Bax and Bak. Preclinical studies have shown promise for targeted inhibition of Bax and Bak in ALS, with results showing the preservation of motor neurons, delayed symptom onset, prolonged survival, and no toxicity concerns in an ALS mouse model.
“We have been investigating the inhibition of Bax and Bak as a potential mechanism of action for neurodegenerative diseases, especially ALS, for a number of years, and we are optimistic about where this research can go,” said
At the end of this two-year agreement, Amylyx will have the right to license and develop any drug candidates that are identified by the research being conducted by SRI. SRI will be responsible for identification of multiple rounds of new Bax and Bak inhibitor compounds. The new analogs will be subjected to a robust screening cascade of biochemical, cell-based assays, and in vitro and in vivo neurodegenerative disease models, leading to the potential identification of a novel lead series of Bax inhibitors that may be ready to enter Investigational New Drug (IND)-enabling studies.
Statements contained in this press release regarding matters that are not historical facts are “forward-looking statements” within the meaning the of Private Securities Litigation Reform Act of 1995, as amended. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding the ability to identify and develop compounds that inhibit Bax and Bak proteins and the potential of such compounds as a treatment for ALS and other neurodegenerative diseases, as well as the potential success of the [collaboration]/[partnership] between Amylyx and SRI. Any forward-looking statements in this communication are based on Amylyx management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. Risks that contribute to the uncertain nature of the forward-looking statements include: the success, cost, and timing of Amylyx’ program development activities, Amylyx’ ability to execute on its strategy, regulatory developments, expectations regarding the timing of regulatory review of Amylyx’ product candidates, the success of pre-clinical and clinical programs, Amylyx’ ability to fund operations, and the impact that the ongoing COVID-19 pandemic will have on Amylyx’ operations, as well as those risks and uncertainties set forth in Amylyx’