SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* Morningside Venture Investments Ltd (Last) (First) (Middle) C/O THC MANAGEMENT SERVICES S.A.M. 3-5 AVENUE DES CITRONNIERS (Street) MONACO O9 MC 98000 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol Amylyx Pharmaceuticals, Inc. [ AMLX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 01/06/2022
	4. If Amendment, Date of Original Filed (Month/Day/Year) 01/25/2022	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	01/11/2022		C		10,415,650	A	(1)	10,415,650	I	See Footnotes(2)(3)
Common Stock	01/11/2022		P		263,158	A	$19	10,678,808	I	See Footnote(2)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series A Preferred Stock	(1)	01/11/2022		C			1,409,035	(1)	(1)	Common Stock	1,409,035	$0.00	0	I	See Footnote(2)
Series B Preferred Stock	(1)	01/11/2022		C			6,410,964	(1)	(1)	Common Stock	6,410,964	$0.00	0	I	See Footnote(2)
Series C-1 Preferred Stock	(1)	01/11/2022		C			974,107	(1)	(1)	Common Stock	974,107	$0.00	0	I	See Footnote(2)
Series C-2 Preferred Stock	(1)	01/11/2022		C			1,621,544	(1)	(1)	Common Stock	1,621,544	$0.00	0	I	See Footnotes(2)(3)

1. Name and Address of Reporting Person* Morningside Venture Investments Ltd (Last) (First) (Middle) C/O THC MANAGEMENT SERVICES S.A.M. 3-5 AVENUE DES CITRONNIERS (Street) MONACO O9 MC 98000 (City) (State) (Zip)

1. Name and Address of Reporting Person* MVIL, LLC (Last) (First) (Middle) C/O 22ND FLOOR, HANG LUNG CENTRE 2-20 PATERSON ST. (Street) CAUSEWAY BAY, HONG KONG K3 (City) (State) (Zip)

Explanation of Responses:

1. Upon the closing of the Issuer's initial public offering, all shares of Series A, Series B, Series C-1 and Series C-2 Preferred Stock (the "Preferred Stock") automatically converted into the number of shares of the Issuer's Common Stock shown in column 4 of Table I without payment or further consideration. The Preferred Stock had no expiration date.

2. Frances Anne Elizabeth Richard, Jill Marie Franklin, Peter Stuart Allenby Edwards and Cheung Ka Ho, are the directors of Morningside Venture Investments Limited ("Morningside") and share voting and dispositive power with respect to the securities held by Morningside and MVIL, LLC ("MVIL LLC"), Morningside's wholly-owned subsidiary. Cheng Yee Wing Betty and Wong See Wai are the managers of MVIL LLC and share voting and dispositive power with respect to the securities held by MVIL LLC. Ms. Cheng and Mr. Wong each disclaim ownership of the securities owned by MVIL LLC.

3. The shares of Series C-2 Preferred Stock and the Common Stock received upon conversion of the C-2 Preferred Stock are held by MVIL LLC.

Remarks:

The Reporting Persons are jointly filing this Form 4 pursuant to Rule 16a-3(j) under the Exchange Act.

	/s/ Frances Anne Elizabeth Richard, for Morningside Venture Investments Limited	03/17/2022
	/s/ Cheng Yee Wing Betty, for MVIL, LLC	03/17/2022
	** Signature of Reporting Person	Date
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                             JOINT FILING AGREEMENT

The undersigned, MVIL, LLC is jointly filing the attached Form 4 with
MORNINGSIDE VENTURE INVESTMENTS LIMITED with respect to the beneficial ownership
of securities of Amylyx Pharmaceuticals, Inc.

For and on behalf of

MVIL, LLC


By: /s/ Cheng Yee Wing Betty
    -------------------------
Cheng Yee Wing Betty, Manager